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Zinc metalloproteinase STE24

mammalian protein found in Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionMay 24, 2026
Entity authorityQ21101211 ↗
Source-derived summary

Zinc metalloproteinase STE24 is a metalloproteinase enzyme associated with laminopathies encoded in humans by the ZMPSTE24 gene.

Zinc metalloproteinase STE24 is involved in the processing of lamin A. Defects in the ZMPSTE24 gene lead to similar laminopathies as defects in lamin A, because the latter is a substrate for the former. In humans, a mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder. Failure to correctly process prelamin A leads to deficient ability to repair DNA double-strand breaks.

As shown by Liu et al., lack of Zmpste24 prevents lamin A formation from its precursor farnesyl-prelamin A. Lack of ZMPSTE24 causes progeroid phenotypes in mice and humans. This lack increases DNA damage and chromosome aberrations and sensitivity to DNA-damaging agents that cause double-strand breaks. Also, lack of ZMPSTE24 allows an increase in non-homologous end joining, but a deficiency in steps leading to homologous recombinational DNA repair.

See also

Progeria

Progeroid syndromes

References

External links

ZMPSTE24+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

ZMPSTE24 human gene location in the UCSC Genome Browser.

ZMPSTE24 human gene details in the UCSC Genome Browser.

Editorial summary

This brief starts where responsible research should: with the source description of “Zinc metalloproteinase STE24” as mammalian protein found in Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current 187-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where Zinc, metalloproteinase and STE24 can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the general reference register because the source frames it as mammalian protein found in Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated May 24, 2026. The linked authority identifier is Q21101211. None of the 0 selected statements returned an explicit reference.

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The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “Zinc metalloproteinase STE24” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.