TRNAIle-lysidine synthase
class of enzymes
tRNAIle-lysidine synthase (EC 6.3.4.19, TilS, mesJ (gene), yacA (gene), isoleucine-specific transfer ribonucleate lysidine synthetase, tRNAIle-lysidine synthetase) is an enzyme with systematic name L-lysine:tRNAIle2–cytidine34 ligase (AMP-forming). This enzyme catalyses the following chemical reaction
tRNAIle2-cytidine34 + L-lysine + ATP
⇌
{\displaystyle \rightleftharpoons }
tRNAIle2-lysidine34 + AMP + diphosphate + H2O
The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34.
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This entry incorporates text from “TRNAIle-lysidine synthase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.