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Research dossier · Science & Nature

WAY-166818

chemical compound

Specimen drawers, botanical folios and brass scientific instruments under study light
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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionDec 23, 2025
Entity authorityQ28209327 ↗
Source-derived summary

WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research. It acts as a highly selective full agonist of the ERβ, with 57- and 164-fold selectivity for the ERβ over the ERα in the rat and mouse, respectively. At the human ERβ and ERα, WAY-166818 has IC50 values of 29 nM and 1227 nM (25-fold difference), respectively. The compound has been verified to cross the blood-brain-barrier in rodents.

Editorial summary

This brief starts where responsible research should: with the source description of “WAY-166818” as chemical compound. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current lead gives the account dated anchors—1227—that can be checked directly. The selected authority fields contribute no independent date. The account is most persuasive where WAY-166818, chemical and compound can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the science & nature register because the source frames it as chemical compound. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Dec 23, 2025. The linked authority identifier is Q28209327. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1227.

Critical limits

Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “WAY-166818”, its source revision and the description used here.
  2. Expand the search: follow WAY-166818 primary sources, WAY-166818 archive and WAY-166818 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “WAY-166818”?
  2. Has classification or technical consensus changed since the cited source?
  3. Is the terminology current, historical or disputed?
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Source & attribution

This entry incorporates text from “WAY-166818” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.