VMA22
protein-coding gene in the species Homo sapiens
Vacuolar ATPase assembly protein VMA22 is a protein that in humans is encoded by the VMA22 gene (formerly CCDC115).
Function
The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016].
References
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Begin with the source’s own compact description: “VMA22” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through VMA22, protein-coding and gene, not as a finished interpretation.
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The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 31, 2026. The linked authority identifier is Q18047563. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2016.
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This entry incorporates text from “VMA22” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.