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Ure2 internal ribosome entry site (IRES)

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionOct 3, 2025
Entity authorityQ17130580 ↗
Source-derived summary

In molecular biology, the Ure2 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of Ure2. It allows 5' cap- and eIF4E-independent translation of an N-terminally truncated form of Ure2. This truncated form lacks the prion-forming domain. It is a 104 nucleotide region, smaller than most viral IRES elements, which forms a stem-loop structure. EIF2A represses this IRES resulting in an inhibition of translation of the N-terminally truncated Ure2.

See also

Ure2

Internal ribosome entry site

Nrf2 internal ribosome entry site (IRES)

References

Further reading

Reineke, LC; Merrick, WC (December 2009). "Characterization of the functional role of nucleotides within the URE2 IRES element and the requirements for eIF2A-mediated repression". RNA. 15 (12): 2264–77. doi:10.1261/rna.1722809. PMC 2779687.

Editorial summary

“Ure2 internal ribosome entry site (IRES)” enters the record as open-knowledge reference entry. Crown Archives preserves that source wording while asking what Ure2, internal and ribosome can confirm, complicate or overturn.

Editorial reviewA dependable orientation record for establishing vocabulary, names and a first evidence trail. The current lead gives the account dated anchors—2009, 1261—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Ure2, internal and ribosome.
Editorial analysis

Why this record matters

“Ure2 internal ribosome entry site (IRES)” is worth following because a concise public description often conceals a longer documentary argument. Here, Ure2, internal and ribosome provides the most credible route into that argument.

Evidence profile

Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Oct 3, 2025. The linked authority identifier is Q17130580. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2009 and 1261.

Critical limits

A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

Best used for
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  • Search vocabulary
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  1. Establish the record: confirm the title “Ure2 internal ribosome entry site (IRES)”, its source revision and the description used here.
  2. Expand the search: follow Ure2 internal ribosome entry site (IRES) primary sources, Ure2 internal ribosome entry site (IRES) archive and Ure2 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

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Source & attribution

This entry incorporates text from “Ure2 internal ribosome entry site (IRES)” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.