U.S. Route 221 in South Carolina
section of U.S. Highway in South Carolina, United States

In the U.S. state of South Carolina, U.S. Route 221 (US 221) is a 126.390-mile (203.405 km) United States Highway within the state. It is part of the United States Numbered Highway System that travels from Perry in North Florida to Lynchburg in Central Virginia. While in South Carolina, the highway travels through Greenwood, Laurens, Woodruff, and Spartanburg. The highway mostly travels through rural parts of the Piedmont region of the state.
Route description
US Route 221 enters McCormick County from Georgia from the top of the J. Strom Thurmond Dam at the southeastern edge of Lake Strom Thurmond. The first site in the state is the Thurmond Lake Overlook. Almost instantly curves to the north but then to the east before seeming to terminate at South Carolina State Highway 28 in Clarks Hill, South Carolina (which is part of the Savannah River Scenic Byway), but in reality turns left and joins the road in a concurrency. US 221/SC 28 runs north and northwesterly often being flanked by a railroad line along the east side as it passes through Modoc where it encounters the Hamilton Branch State Park and Recreation Area, and later Parksville which contains the Parksville State Recreation Area. The road widens to four lanes as it enters Plum Branch and after a road to the Plum Branch Yacht Club, has a blinker light intersection with the western terminus of South Carolina Highway 283 and a local road named Collier Street.
Shifting a bit further away from the coast it eventually enters the town of McCormick.
The public source identifies “U.S. Route 221 in South Carolina” as section of U.S. Highway in South Carolina, United States. This brief keeps that definition visible, then builds a research path around Route, South and Carolina.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Jul 24, 2026. The linked authority identifier is Q4296895. 1 of 1 selected statements include explicit references; 0 carry qualifiers and 0 use preferred rank.
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This entry incorporates text from “U.S. Route 221 in South Carolina” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.