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Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionAug 3, 2025
Entity authorityQ576882 ↗
Source-derived summary

In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (EC 2.4.1.79) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (11)-ceramide

⇌

{\displaystyle \rightleftharpoons }

UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)- beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide

The 3 substrates of this enzyme are UDP-N-acetyl-D-galactosamine, [[alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-]], and (11)-ceramide, whereas its 3 products are UDP, [[N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-]], and [[beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide]].

Wrongly characterized previously as globotriosylceramide beta-1,6-N-acetylgalactosaminyl-transferase (EC 2.4.1.154

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact osyl-(1->4)-beta-D-glucosyl-(11)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.

References

Chien JL, Williams T, Basu S (1973). "Biosynthesis of a globoside-type glycosphingolipid by a -N-acetylgalactosaminyltransferase from embryonic chicken brain". J. Biol. Chem. 248 (5): 1778–85. doi:10.1016/S0021-9258(19)44258-0.

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The public source identifies “Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase” as class of enzymes. This brief keeps that definition visible, then builds a research path around Globotriaosylceramide, 3-beta-N-acetylgalactosaminyltransferase and class.

Editorial reviewA concise reference frame for defining the subject, testing terminology and identifying the institution closest to the evidence. The current lead gives the account dated anchors—1973, 1778, 1016—that can be checked directly. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with Globotriaosylceramide, 3-beta-N-acetylgalactosaminyltransferase and class providing the first useful test.
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This entry incorporates text from “Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.