UCN3
protein-coding gene in the species Homo sapiens
Urocortin-3 is a protein that, in humans, is encoded by the UCN3 gene.
It belongs to the corticotropin-releasing hormone family.
Function
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors.
In the brain it may be responsible for the effects of stress on appetite. In humans, it is also expressed by alpha cells and beta cells in the pancreas and is co-released with glucagon and insulin to promote somatostatin release from neighboring delta cells, which provides negative feedback on glucagon and insulin secretion.
“UCN3” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what UCN3, protein-coding and gene can confirm, complicate or overturn.
Why this record matters
“UCN3” is worth following because a concise public description often conceals a longer documentary argument. Here, UCN3, protein-coding and gene provides the most credible route into that argument.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 14, 2026. The linked authority identifier is Q18048950. None of the 0 selected statements returned an explicit reference.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
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This entry incorporates text from “UCN3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.