Special routes of U.S. Route 21
Wikimedia list article

Several special routes of U.S. Route 21 (US 21) exist. In order from south to north, they are as follows.
Beaufort business loop
U.S. Highway 21 Business (US 21 Bus.) is a 5.400-mile (8.690 km) business route in Beaufort, South Carolina, that travels along Sea Island Parkway, Carteret Street, and Boundary Street.
Yemassee alternate route
Rowesville alternate route
Orangeburg alternate route
Orangeburg business loop 1
U.S. Highway 21 Business (US 21 Bus.) originally traversed Orangeburg, South Carolina, along Broughton Street (in concurrency with US 178 Bus.), Park Street, and Columbia Road. In 1967, the business loop was decommissioned after the establishment of the second business loop through Orangeburg; the old alignment continues as US 178 Bus. (Broughton Street) and US 21 Conn. (Park and Columbia streets).
Orangeburg business loop 2
U.S. Highway 21 Business (US 21 Bus.) is a 2.730-mile (4.394 km) business route of US 21 in Orangeburg, South Carolina. It begins at the intersection of US 21 and South Carolina Highway 4 (SC 4) and then traverses along parts of Charleston Highway and Magnolia Street, before ending at Chestnut Street (US 21).
Orangeburg bypass route
Orangeburg connector route
U.S. Highway 21 Connector (US 21 Conn.) is a 1.480-mile (2.382 km) connector route of US 21 in Orangeburg, South Carolina, that is unsigned.
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