U.S. Route 21
highway in the United States

U.S. Route 21 or U.S. Highway 21 (US 21) is a north–south United States Numbered Highway, spanning 393 miles (632 km) from Hunting Island State Park, South Carolina, to Wytheville, Virginia. The route traverses three states, South Carolina, North Carolina, and Virginia. It connects southeastern cities, including Columbia, South Carolina, and Charlotte, North Carolina.
US 21 starts at Hunting Island State Park, bypasses Beaufort, South Carolina, and then heads north across the low country, paralleling Interstate 77 (I-77) through urban and rural areas before entering North Carolina. In North Carolina, US 21 frequently merges with and splits from I-77. The route enters Virginia, passing through hilly terrain before ending at the intersection of Interstate 81 (I-81) / U.S. Route 52 (US 52) in Wytheville.
Despite the "1" indicating that it is a major north–south highway, US 21 only travels through three states and is no longer a cross-country route, as many sections have been replaced by I-77 in Ohio and West Virginia. Historically, US 21 was longer before the Interstate Highway System was established. US 21 originally ran from Cleveland, Ohio, to Yemassee, South Carolina, it was later extended to Beaufort and Hunting Island State Park. Over time, its length was reduced, making it the second-shortest major north–south route after U.S. Route 91 (US 91).
The public source identifies “U.S. Route 21” as highway in the United States. This brief keeps that definition visible, then builds a research path around Route, highway and United.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Aug 12, 2026. The linked authority identifier is Q408104. 1 of 1 selected statements include explicit references; 0 carry qualifiers and 0 use preferred rank.
The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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This entry incorporates text from “U.S. Route 21” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.