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2,4,6-Triisopropylbenzenesulfonyl azide

chemical compound

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 7, 2026
Entity authorityQ72513621 ↗
Source-derived summary

2,4,6-Triisopropylbenzenesulfonyl azide (trisyl azide) is an organic chemical used as a reagent to supply azide for electrophilic amination reactions, such as for the asymmetric synthesis of unnatural amino acids. Introduction of an azide on the α carbon of carboxylic acid derivatives using trisyl azide is an efficient alternative to electrophilic halogenation followed by nucleophilic substitution using anionic azide. Using an oxazolidinone as chiral auxiliary typically gives good induction of the stereochemistry at the α position. Subsequent reduction converts the α-azide to an α-amine.

References

Further reading

Calmes, M.; Daunis, J. (1999). "How to build optically active α-amino acids". Amino Acids. 16 (3–4): 215–250. doi:10.1007/BF01388170. PMID 10399014.

Editorial summary

The public source identifies “2,4,6-Triisopropylbenzenesulfonyl azide” as chemical compound. This brief keeps that definition visible, then builds a research path around 6-Triisopropylbenzenesulfonyl, azide and chemical.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current lead gives the account dated anchors—1999, 1007—that can be checked directly. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with 6-Triisopropylbenzenesulfonyl, azide and chemical providing the first useful test.
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Why this record matters

A short description can identify a subject without explaining its stakes. For “2,4,6-Triisopropylbenzenesulfonyl azide”, the useful work is to connect “chemical compound” to the records capable of establishing context and consequence.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 7, 2026. The linked authority identifier is Q72513621. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1999 and 1007.

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Source & attribution

This entry incorporates text from “2,4,6-Triisopropylbenzenesulfonyl azide” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.