Trazium
chemical compound
Trazium (EGYT-3,615) is an antidepressant drug which was never marketed. It has psychostimulant-like effects and its actions appear to be mediated by the dopaminergic and adrenergic systems. It was formulated as a salt with ethanesulfonic acid and given the generic name trazium esilate (INN).
Synthesis
Precursors: Background literature:
Ex 5: The Grignard reaction between para-chlorophenylmagnesium bromide and 1-cyanoisoquinoline [1198-30-7] (1) gave 1-(4-chlorobenzoyl)isoquinoline, PC12243105 (2). The reaction of this with O-tosylhydroxylamine [52913-14-1] gives (2-aminoisoquinolin-2-ium-1-yl)-(4-chlorophenyl)methanone;4-methylbenzenesulfonate, PC23311140 (3). The reaction of this a mixture of formamide and phosphoryl chloride gave the ring. The addition of perchloric acid led to 1-(4-Chlorophenyl)[1,2,4]triazino[6,1-a]isoquinolin-5-ium perchlorate [82319-70-8] (4). The reaction of this with triethylammonium bromide is said to give (4).
Patent:
Ex 1: 1-(4-chlorophenyl)-as-triazino[6,1-a]isoquinolinium-bromide [82319-85-5] (1) is reacted with an aqueous solution of acetonitrile to give the title compound.
Ex 2: Treatment with ethanesulfonic acid in acetonitrile then prepares the esilate salt.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Dec 24, 2025. The linked authority identifier is Q7836500. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1198.
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