Transmembrane protein 255A
mammalian protein found in Homo sapiens
Transmembrane protein 255A is a protein that is encoded by the TMEM255A gene. TMEM255A is often referred to as family with sequence similarity 70, member A (FAM70A). The TMEM255A protein is transmembrane and is predicted to be located the nuclear envelope of eukaryote organisms.
Gene
The TMEM25A gene (often referred to as Family with Sequence Similarity 70 Member A; FAM70A) is located on Xq24, spanning 60,555 base pairs. TMEM255A is flanked by the genes ATPase Na+/K+ transporting family member beta 4 (ATP1B4) and NFKB activating protein pseudogene 1 (NKAPP1).
mRNA
There are three variants of the transcript seen, where isoform 1 is the longest. The 5’- and 3’- UTRs of the mRNA spans 227 and 2207 base pairs, respectively, and are predicted to contain several stem-loops. The mRNA is 3512 base pairs long and the gene consists of 9 exons.
Protein
The longest protein encoded for is isoform 1, which spans 349 amino acids, and is predicted to have a molecular weight at 38 kDa and isoelectric point at pH 7.89. Compared to the average vertebrate protein, TMEM255A is rich in aspartic acid, isoleucine, proline and tyrosine, and relatively poor in glutamic acid and lysine.
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