TMEM230
protein-coding gene in the species Homo sapiens
TMEM230 or transmembrane protein 230 is a protein that in humans is encoded by the TMEM230 gene.
Function
This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicles in the neuron and may be involved in synaptic vesicle trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease.
More recent research demonstrates that TMEM230 has a role in the secretory pathway of cells, and in human normal and disease development associated with the cellular functions of sprouting, migration and tissue remodeling. Single-cell transcriptomic analysis supported that aberrantly elevated levels of TMEM230 promotes autoimmunity, such as rheumatoid arthritis. TMEM230 was also identified in the most aggressive brain cancer. In a study of human patient transcriptomic sequencing analysis with glioblastoma multiforme (GBM) combined with in vitro tumor glioma cell analysis, high expression of TMEM230 was correlated with vascular mimicry behavior and aggressive formation of "leaky blood vessels". Shortened life-span and high mortality observed in patients with GBM was hypothesized to be due to high TMEM230 expression promoting unregulated secretion of cellular factors and vesicles with destructive tissue remodeling capacity. TMEM230 was identified with genes co-regulated with endoplasmic reticulum and the Golgi complex, motor proteins, metalloproteins (such as metalloproteinases), and mitochondria and extracellular secretion activities.
This brief starts where responsible research should: with the source description of “TMEM230” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.
Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Aug 17, 2026. The linked authority identifier is Q18039561. None of the 0 selected statements returned an explicit reference.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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This entry incorporates text from “TMEM230” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.