Thio-THIP
chemical compound
Thio-THIP, also known as 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol, is a low-potency GABAA receptor very weak partial agonist or antagonist related to gaboxadol (THIP). It is also a weak GABAA-ρ receptor antagonist and a weak GABA reuptake inhibitor. The drug has three orders of magnitude lower potency as a GABAA receptor modulator than gaboxadol. This is unlike the case of muscimol and thiomuscimol, which are almost equipotent. Like gaboxadol, thio-THIP is a zwitterion. It may cross the blood–brain barrier similarly to gaboxadol. Thio-THIP was developed and described by Povl Krogsgaard-Larsen and colleagues by 1981.
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This entry incorporates text from “Thio-THIP” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.