TBC domain
InterPro Domain
The TBC domain is an evolutionarily conserved protein domain found in all eukaryotes. It is approximately 180 to 200 amino acids long. The domain is named for its initial discovery in the proteins Tre-2, Bub2, and Cdc16.
TBC family members act as GTPase-activating proteins (GAPs) for small GTPases in regulating the cell cycle. For example, Rab activity is modulated in part by GAPs, and many RabGAPs share a Tre2/Bub2/Cdc16(TBC)-domain architecture, suggesting that TBC domain-containing proteins may behave similarly.
Examples
USP6 and CDC16 contain TBC domains. In addition, all proteins in the TBC family contain this domain:
Functions
TBC mainly functions as a specific Rab GAP (GTPases activating proteins) by being used as tools to inactivate specific membrane trafficking events. GAPs serve to increase GTPase activity by contributing the residues to the active site and promoting conversion from GTP to GDP form. Such activity of TBC proteins does not always require a close physical interaction although few TBC proteins have shown clear GAP activity towards their binding Rabs. Rab families contribute to defining organelles and controlling specificity and rate of transport through individual pathways.
“TBC domain” enters the record as interPro Domain. Crown Archives preserves that source wording while asking what domain, InterPro and Domain can confirm, complicate or overturn.
Why this record matters
“TBC domain” is worth following because a concise public description often conceals a longer documentary argument. Here, domain, InterPro and Domain provides the most credible route into that argument.
Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Mar 23, 2025. The linked authority identifier is Q24723343. None of the 0 selected statements returned an explicit reference.
The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “TBC domain”, its source revision and the description used here.
- Expand the search: follow TBC domain primary sources, TBC domain archive and domain research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “TBC domain”?
- What terminology or title could unlock a more precise catalogue search?
- Which institution is responsible for the underlying evidence?
Search terms from this dossier
This entry incorporates text from “TBC domain” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.