TRPP
family of transport proteins
TRPP (transient receptor potential polycystic) is a family of transient receptor potential ion channels which when mutated can cause polycystic kidney disease.
Subcategories
TRPP subunits can be divided into two subcategories depending on structural similarity.
Polycystic Kidney Disease 1 (PKD1)-Like Group
The first group, polycystic kidney disease 1 (PKD1)-like, contains polycystin-1 (Previously known as TRPP1), PKDREJ, PKD1L1, PKD1L2, and PKD1L3. Polycystin-1 contains numerous N-terminal adhesive domains that are important for cell-cell contact. This group of subunits also contain a large extracellular domain with numerous polycystin motifs. These motifs are of unknown function and are located between the S6 and S7 segments. The large intracellular C-terminal segment of TRPP1 seems to interact with TRPP2 to act as a signaling complex.
Polycystic Kidney Disease 2 (PKD2)-Like Group
This group of TRPP members (previously known as TRPP2-like) are: TRPP1 (previously known as TRPP2 or PKD2), TRPP2 (previously known as TRPP3 or PKDL2), and TRPP3 (previously known as TRPP5 or polycystin-L2). Unlike the previous group, which contain 11 membrane-spanning segments, this group resemble other TRP channels, having 6 membrane-spanning segments with intracellular N- and C-termini. All of the members of this group contain a coiled coil region in their C-terminus involved in the interaction with the polycystin-1 group.
“TRPP” enters the record as family of transport proteins. Crown Archives preserves that source wording while asking what TRPP, family and transport can confirm, complicate or overturn.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Dec 20, 2024. The linked authority identifier is Q7671486. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “TRPP” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.