CACrown ArchivesThe cinema collection
EN/FR
Search
Menu
Research dossier · Science & Nature

Thyrotropin-releasing hormone receptor

protein-coding gene in the species Homo sapiens

Specimen drawers, botanical folios and brass scientific instruments under study light
Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionMar 10, 2024
Entity authorityQ14905267 ↗
Source-derived summary

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone.

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a Gαq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.

References

Further reading

External links

"Thyrotropin-Releasing Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-08. Retrieved 2007-10-25.

Editorial summary

“Thyrotropin-releasing hormone receptor” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what Thyrotropin-releasing, hormone and receptor can confirm, complicate or overturn.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current lead gives the account dated anchors—2012, 2007—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Thyrotropin-releasing, hormone and receptor.
Editorial analysis

Why this record matters

“Thyrotropin-releasing hormone receptor” is worth following because a concise public description often conceals a longer documentary argument. Here, Thyrotropin-releasing, hormone and receptor provides the most credible route into that argument.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Mar 10, 2024. The linked authority identifier is Q14905267. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2012 and 2007.

Critical limits

Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “Thyrotropin-releasing hormone receptor”, its source revision and the description used here.
  2. Expand the search: follow Thyrotropin-releasing hormone receptor primary sources, Thyrotropin-releasing hormone receptor archive and Thyrotropin-releasing research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “Thyrotropin-releasing hormone receptor”?
  2. Has classification or technical consensus changed since the cited source?
  3. Which observation, specimen, dataset or publication supports the account?
Subject index

Search terms from this dossier

Source & attribution

This entry incorporates text from “Thyrotropin-releasing hormone receptor” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.