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TGFB1I1

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJun 3, 2026
Entity authorityQ18031969 ↗
Source-derived summary

Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene. TGFB1I1 is also sometimes called HIC-5 (Hydrogen Peroxide-Inducible Clone-5) or ARA55 (Androgen Receptor Coactivator 55kDA).

As its multiple names suggests, TGFB1I1 a protein whose expression is induced by TGFB1 and is both inducible by hydrogen peroxide, and a coactivator of the androgen receptors.

TGFB1I1 plays a role in processes of cell growth, proliferation, migration, differentiation, and senescence in multiple contexts including in cancer. TGFB1I1 is most localized at focal adhesion complexes of cells, although it may be found active in the cytosol, nucleus and cell membrane as well.

Functions

Transforming growth factor beta-1-induced transcript 1 plays a role in a number of cell functions. Originally, TGFB1I1 was isolated as a senescence-inducing gene from mouse osteoblastic cells through treatment with transforming growth factor beta-1 and hydrogen peroxide. During this, TGFB1I1 was also being independently discovered by numerous other groups and was characterized as a focal adhesion protein, an androgen and glucocorticoid receptor co-activator, a negative regulator of muscle differentiation, and major player in the recovery of arterial media.

Interactions

TGFB1I1 has been shown to interact with:

See also

Transcription coregulator

References

Further reading

External links

TGFB1I1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

NURSA C148

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Editorial summary

This brief starts where responsible research should: with the source description of “TGFB1I1” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA sound reference starting point where classification, measurement and the date of the underlying evidence remain visible. The current 237-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where TGFB1I1, protein-coding and gene can be independently traced.
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Why this record matters

The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jun 3, 2026. The linked authority identifier is Q18031969. None of the 0 selected statements returned an explicit reference.

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Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “TGFB1I1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.