Sulbactam
chemical compound
Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
It was patented in 1977 and approved for medical use in 1986.
Medical uses
The combination ampicillin/sulbactam (Unasyn) is available in the United States.
The combination cefoperazone/sulbactam (Sulperazon) is available in many countries but not in the United States.
The co-packaged combination sulbactam/durlobactam was approved for medical use in the United States in May 2023.
Mechanism
Sulbactam is primarily used as a suicide inhibitor of β-lactamase, shielding more potent beta-lactams such as ampicillin. Sulbactam itself contains a beta-lactam ring, and has weak antibacterial activity by inhibiting penicillin binding proteins (PBP) 1 and 3, but not 2.
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This entry incorporates text from “Sulbactam” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.