EZS-8
pharmaceutical compound
EZS-8, also known as 3-(2-aminoethyl)quinazoline-2,4-dione, is a very-low-potency serotonin 5-HT2A receptor partial agonist related to ketanserin. It has about 0.15% of the potency (EC50Tooltip half-maximal effective concentration = 66,000 nM) and 46% of the efficacy (EmaxTooltip maximal efficacy) of serotonin as a serotonin 5-HT2A receptor agonist in vitro. The N-(2-methoxy)benzyl analogue of EZS-8, RH-34, has 250-fold greater potency as a serotonin 5-HT2A receptor agonist in comparison. EZS-8 was first described in the scientific literature by 1999. N-Benzyl derivatives of EZS-8 like RH-34 had been described as early as 1996 or 1998. Some other analogues of EZS-8 such as WL299 and WL163 have been described as well.
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This entry incorporates text from “EZS-8” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.