Substituted piperazine
class of chemical compounds
Substituted piperazines are a class of chemical compounds based on a piperazine core. Some are used as recreational drugs and some are used in scientific research.
List of substituted piperazines
Benzylpiperazines
Phenylpiperazines
ortho-Substituted
2-Chlorophenylpiperazine (oCPP)
2-Methylphenylpiperazine (oMPP)
2-Methoxyphenylpiperazine (oMeOPP)
Mefeclorazine
Vortioxetine
Enpiprazole is known to produce oCPP as a metabolite. It was initially anticipated to produce oMeOPP as a metabolite, but this proved not to be the case.
meta-Substituted
3-Chlorophenylpiperazine (mCPP)
3-Methoxyphenylpiperazine (mMeOPP)
3-Trifluoromethylphenylpiperazine (TFMPP)
1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP)
Trazodone, nefazodone, etoperidone, mepiprazole, and others produce mCPP as a metabolite.
para-Substituted
4-Chlorophenylpiperazine (pCPP)
4-Fluorophenylpiperazine (pFPP)
4-Methylphenylpiperazine (pMPP)
4-Methoxyphenylpiperazine (pMeOPP, MeOPP)
4-Nitrophenylpiperazine (pNPP; PAL-175) – selective partial serotonin releasing agent
4-Trifluoromethylphenylpiperazine (pTFMPP)
Multiple substitutions
2,3-Dichlorophenylpiperazine (2,3-DCPP)
3,4-Dichlorophenylpiperazine (3,4-DCPP)
2,3-Dimethylphenylpiperazine (DMPP)
3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP; PAL-179) – selective partial serotonin releasing agent
Others
1-Phenylpiperazine (PP)
Other arylpiperazines
1-(1-Naphthyl)piperazine (1-NP)
1-(2-Pyrimidinyl)piperazine (1-PP)
6-Chloro-2-(1-piperazinyl)quinoxaline (CPQ)
ORG-12962 (1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine)
Quipazine (2-piperazin-1-ylquinoline)
Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.
By drug class
Activities
See also
Substituted α-alkyltryptamine
Substituted amphetamine
Substituted cathinone
Substituted methylenedioxyphenethylamine
Substituted phenethylamine
Substituted phenylmorpholine
Substituted tryptamine
References
External links
"BZP/piperazines". European Union Drugs Agency (EUDA).
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