Antihemorrhagic
substance that promotes hemostasis
An antihemorrhagic (British English: antihaemorrhagic) agent is a substance that promotes hemostasis (a process which stops bleeding). It may also be known as a hemostatic (also spelled haemostatic) agent.
Antihemorrhagic agents used in medicine have various mechanisms of action:
Systemic drugs work by inhibiting fibrinolysis or promoting coagulation.
Locally acting hemostatic agents work by causing vasoconstriction or promoting platelet aggregation.
Medical uses
Hemostatic agents are used during surgical procedures to achieve hemostasis and are categorized as hemostats, sealants and adhesives. They vary based on their mechanism of action, composition, ease of application, adherence to tissue, immunogenicity and cost. These agents permit rapid hemostasis, better visualization of the surgical area, shorter operative times, decreased requirement for transfusions, decreased wound healing time and overall improvement in patient recovery time.
Types
Systemic
There are several classes of antihemorrhagic drugs used in medicine. These include antifibrinolytics, blood coagulation factors, fibrinogen, and vitamin K.
Local
Topical hemostatic agents have been gaining popularity for use in emergency bleeding control, especially in military medicine. They are available in three forms –as a granular powder poured on wounds, as a styptic pencil and embedded in a dressing.
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