Streptogramin
class of natural cyclic peptide antibiotics produced by certain subspecies of Streptomyces
Streptogramins are a class of antibiotics. They work as protein synthesis inhibitors.
Streptogramins are effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two of the most rapidly growing strains of multidrug-resistant bacteria. They fall into two groups: streptogramin A (23-membered macrolide) and streptogramin B (depsipeptide). The two groups act synergistically. They are naturally produced in a 3:7 ratio; most formulations keep this ratio.
Members include:
Quinupristin/dalfopristin, made by chemically modifying pristinamycin (semisynthesis)
Pristinamycin, made by Streptomyces pristinaespiralis
Virginiamycin, made by Streptomyces virginiae and others
Linopristin/flopristin, made by semisynthesis. experimental streptogramin in clinical trials for the treatment of respiratory tract infections.
The public source identifies “Streptogramin” as class of natural cyclic peptide antibiotics produced by certain subspecies of Streptomyces. This brief keeps that definition visible, then builds a research path around Streptogramin, class and natural.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Jan 10, 2026. The linked authority identifier is Q739867. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Streptogramin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.