Silver–Russell syndrome
growth disorder
Silver–Russell syndrome (SRS), also called Silver–Russell dwarfism, is a rare congenital growth disorder. In the United States it is usually referred to as Russell–Silver syndrome, and Silver–Russell syndrome elsewhere. It is one of 200 types of dwarfism and one of five types of primordial dwarfism.
Silver–Russell syndrome occurs in approximately one out of every 50,000 to 100,000 births. Males and females seem to be affected with equal frequency.
Signs and symptoms
Although confirmation of a specific genetic marker is in a significant number of individuals, there are no tests to clearly determine if this is what a person has. As a syndrome, a diagnosis is typically given for children upon confirmation of the presence of several symptoms listed below.
Symptoms are intrauterine growth restriction (IUGR) combined with some of the following:
Often small for gestational age (SGA) at birth (birth weight less than 2.8 kg), or within two or more standard deviations away from the mean weight of 2.8 kg.
Feeding problems: the baby is uninterested in feeding and takes only small amounts with difficulty
Hypoglycemia
Excessive sweating as a baby, especially at night, and a greyness or pallor of the skin. This may be a symptom of hypoglycemia
Triangular face with a small jaw and a pointed chin that tends to lessen slightly with age.
The public source identifies “Silver–Russell syndrome” as growth disorder. This brief keeps that definition visible, then builds a research path around Silver, Russell and syndrome.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Sep 21, 2026. The linked authority identifier is Q2142496. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Silver–Russell syndrome” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.