Secretoneurin
peptide in Homo sapiens
Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC).
Function
Secretoneurin is involved in chemotaxis of monocytes and eosinophils (comparable in potency to interleukin 8) and endothelial cells and in regulation of endothelial cell proliferation. Highest secretoneurin levels are found in anterior pituitary, followed by adrenal medulla and posterior pituitary hypothalamus (2- to 6-fold lower levels in other brain regions investigated). Secretoneurin has been shown to have potent angiogenic activity in vivo in mouse cornea model and in vitro in a 3-dimensional gel. Secretoneurin also stimulates dopamine release from the central striatal neurons and basal ganglia.
Signaling
PI3 kinase, phosphodiesterase and phospholipase D inhibition inhibits its pro-migration effects, but blocking PKC and tyrosine kinases has not been shown to have effect. Downstream to these ERK type MAP kinase and AKT are activated.
“Secretoneurin” enters the record as peptide in Homo sapiens. Crown Archives preserves that source wording while asking what Secretoneurin, peptide and Homo can confirm, complicate or overturn.
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Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Mar 25, 2026. The linked authority identifier is Q36375672. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Secretoneurin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.