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SKAP2

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 17, 2025
Entity authorityQ18033546 ↗
Source-derived summary

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.

Function

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells, but particularly specific in macrophages. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation. It interacts with Signal-regulatory protein alpha and directs integrin-activated cytoskeletal reorganization in macrophages.

Editorial summary

The public source identifies “SKAP2” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around SKAP2, protein-coding and gene.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current 87-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its value is orientation rather than verdict, with SKAP2, protein-coding and gene providing the first useful test.
Editorial analysis

Why this record matters

A short description can identify a subject without explaining its stakes. For “SKAP2”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jul 17, 2025. The linked authority identifier is Q18033546. None of the 0 selected statements returned an explicit reference.

Critical limits

A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “SKAP2”, its source revision and the description used here.
  2. Expand the search: follow SKAP2 primary sources, SKAP2 archive and SKAP2 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “SKAP2”?
  2. Which observation, specimen, dataset or publication supports the account?
  3. Has classification or technical consensus changed since the cited source?
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Source & attribution

This entry incorporates text from “SKAP2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.