SB-616234
pharmaceutical compound
SB-616234 is a selective serotonin 5-HT1B receptor antagonist. In terms of affinity, it shows 50-fold selectivity for the serotonin 5-HT1B receptor over the serotonin 5-HT1D receptor and greater than 100-fold selectivity for the serotonin 5-HT1B receptor over other serotonin receptors. The drug is a silent antagonist of the serotonin 5-HT1B receptor. It dose-dependently increases serotonin levels in the dentate gyrus of the hippocampus in rodents via blockade of serotonin 5-HT1B autoreceptors. In addition, it augments the increased serotonin levels induced by the selective serotonin reuptake inhibitor (SSRI) paroxetine in this brain area in rodents. The drug produces antidepressant- and anxiolytic-like effects in rodents and anxiolytic-like effects in monkeys. It is orally active. SB-616234 was first described in the scientific literature by 2003.
“SB-616234” enters the record as pharmaceutical compound. Crown Archives preserves that source wording while asking what SB-616234, pharmaceutical and compound can confirm, complicate or overturn.
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