S1PR2
protein-coding gene in the species Homo sapiens
Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).
Function
This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation. It has also been shown to interact with Nogo-A (RTN4), an neurite outgrowth inhibitor. S1PR2 is expressed in neuronal and vascular cells and is crucial for the migration and growth of developing and injured neuronal and vascular system.
Evolution
Paralogues
Source:
S1PR1
S1PR3
S1PR5
S1PR4
LPAR2
LPAR1
LPAR3
CNR1
GPR6
MC3R
GPR12
GPR3
MC4R
MC1R
CNR2
MC5R
MC2R
GPR119
See also
Lysophospholipid receptor
References
Further reading
External links
"Lysophospholipid Receptors: S1P2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Begin with the source’s own compact description: “S1PR2” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through S1PR2, protein-coding and gene, not as a finished interpretation.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Oct 3, 2025. The linked authority identifier is Q18033976. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2016 and 2008.
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