Coenzyme Q5, methyltransferase
protein-coding gene in the species Homo sapiens
Coenzyme Q5, methyltransferase, more commonly known as COQ5, is an enzyme involved in the electron transport chain. COQ5 is located within the mitochondrial matrix and is a part of the biosynthesis of ubiquinone.
Function
COQ5 has the role of catalyst in the C-methylation in the coenzyme Q biosynthesis, on the benzoic ring of CoQ6, the biosynthetic intermediate, in both in humans and yeast Saccharomyces cerevisiae. COQ5 is one of the eleven polypeptides in yeast, that are essential for Q production. Moreover, it assembles with the CoQ-synthome, a multi-subunit complex. In humans, primary Q deficiency happens due to many COQ genes mutating. And diseases such as mitochondrial, cardiovascular, kidney and neurodegenerative diseases, are results of the decrease in Q biosynthesis. Development of soluble COQ5 proteins can be applied to other mitochondrial proteins. Coenzyme Q10 Deficiency is associated with COQ5. Therefore, to maintain CoQ10 levels in human cells, COQ5 is required.
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