Nicotinyl alcohol
chemical compound
Nicotinyl alcohol (pyridylcarbinol) is a niacin derivative used as a hypolipidemic agent and as a vasodilator. It causes flushing and may decrease blood pressure.
It appears as a crystal that dissolves in water and alcohol with ease, also soluble in ether; melting range 147–148 °C.
Nicotinic acid is a brief peripheral vasodilator; this compound was made to make its action longer and effective. It provokes cutaneous flushing in head and upper thorax with heat, but with no major effects in blood pressure. It is used in peripheral vascular diseases, like arteriosclerosis obliterans, Raynaud's disease, thromboangiitis obliterans (Buerger's disease), arterial embolism, chilblains or migraine associated with vascular spasm.
Fischer and Tebrock worked with this drug in more than two hundred patients for more than three years, achieving effective improvements, mainly in symptoms related to intermittent claudication, ulcer healing and others.
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This entry incorporates text from “Nicotinyl alcohol” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.