Roger J. Davis
PhD Investigator at the Howard Hughes Medical Institute
Roger J. Davis. is a biochemist and molecular biologist born in Great Britain. He is the H. Arthur Smith Endowed Chair and serves as Professor and Chair of the Program in Molecular Medicine at the University of Massachusetts Chan Medical School. His work focuses on signaling pathways related to cellular stress,including the c-Jun N-terminal kinase (JNK) pathway. Davis molecularly cloned human JNK and has used biochemical, molecular, and mouse model techniques to study the physiological roles and molecular mechanisms of JNK. The goal of his laboratory is to identify molecular targets within stress signaling pathways that can be used to develop treatments for diseases linked to cellular inflammation, including cancer, metabolic disorders, and ischemia, his lab seeks to identify molecular targets within stress signaling pathways.
His recent studies have focussed on the role of hepatic JNK in the development of the metabolic syndrome, which includes obesity, steatosis and insulin resistance) caused by the consumption of a high-fat diet. His work investigates the JNK-dependent regulation of the nuclear hormone receptor complex PPARα/RXRα. These studies aim to identify potential therapeutic targets.
Academic career
Student at Queens' College, Cambridge University, UK: undergraduate student (1976-1979)
Damon Runyon Post-doctoral Fellow, University of Massachusetts Medical School, Worcester, MA 01655, USA (1984 -1985).
Assistant Professor, Department of Biochemistry, University of Massachusetts Medical School, (1985 – 1989).
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