COA7
protein-coding gene in the species Homo sapiens
Cytochrome c oxidase assembly factor 7 (putative) (COA7), also known as Beta-lactamase hap-like protein, Respiratory chain assembly factor 1 (RESA1), Sel1 repeat-containing protein 1 (SELRC1), or C1orf163, is a protein that in humans is encoded by the COA7 gene. The protein encoded by COA7 is an assembly factor important for the mitochondrial respiratory chain. Mutations in COA7 have been associated with cytochrome c oxidase deficiency resulting in spinocerebellar ataxia with axonal neuropathy type 3 and mitochondrial myopathy.
Structure
COA7 is located on the p arm of chromosome 1 in position 32.3 and has 3 exons. The COA7 gene produces a 25.7 kDa protein composed of 231 amino acids. COA7, the protein encoded by this gene, is a member of the hcp beta-lactamase family. This protein has a series of 5 Sel1-like tetratricopeptide repeat domains. It is also believed to be a soluble mitochondrial protein that contains large amounts of cysteine. Additionally, COA7 contains an N-acetylalanine amino acid modification at position 2.
Function
COA7 is a protein assembly factor that is important for normal mitochondrial respiratory chain activity.
Begin with the source’s own compact description: “COA7” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through COA7, protein-coding and gene, not as a finished interpretation.
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The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Sep 2, 2026. The linked authority identifier is Q18045870. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “COA7” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.