40S ribosomal protein S19
protein-coding gene in the species Homo sapiens
40S ribosomal protein S19 is a protein that in humans is encoded by the RPS19 gene.
Function
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Clinical significance
Mutations in this gene cause Diamond–Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed.
The public source identifies “40S ribosomal protein S19” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around ribosomal, protein and protein-coding.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Aug 25, 2025. The linked authority identifier is Q18031308. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “40S ribosomal protein S19” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.