RO4929097
chemical compound
RO4929097 (RG-4733) is a gamma secretase inhibitor being studied as an anti-cancer drug. Targeting gamma secretase inhibits NOTCH signaling, which is upregulated in many forms of cancer. The drug was initially developed by Roche for the treatment of Alzheimer's disease, but current research focuses on cancer. Production was halted in 2010, but began again in 2014.
Research
Over 35 phase I and II clinical trials have been performed, but no phase III trials have yet commenced.
Phase II studies have investigated the use of RO4929097 in ovarian cancer, renal cell carcinoma in patients that were unsuccessful on anti-VEGF treatments, metastatic pancreatic cancer, advanced brain tumors, and relapsed non-small cell lung cancer.
Other planned clinical trials were terminated, because the drug became unavailable.
“RO4929097” enters the record as chemical compound. Crown Archives preserves that source wording while asking what RO4929097, chemical and compound can confirm, complicate or overturn.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Aug 8, 2026. The linked authority identifier is Q27088591. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2010 and 2014.
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This entry incorporates text from “RO4929097” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.