Response evaluation criteria in solid tumors
internationally recognized set of published rules used for evaluation of cancer treatment
Response evaluation criteria in solid tumors (RECIST) is a set of published rules that define when tumors in cancer patients improve ("respond"), stay the same ("stabilize"), or worsen ("progress") during treatment. The criteria were published in February 2000 by an international collaboration including the European Organisation for Research and Treatment of Cancer (EORTC), National Cancer Institute of the United States, and the National Cancer Institute of Canada Clinical Trials Group. Today, the majority of clinical trials evaluating cancer treatments for objective response in solid tumors use RECIST. These criteria were developed and published in February 2000, and subsequently updated in 2009.
The criteria are specifically not meant to determine whether patients have improved or not, as these are tumor-centric, not patient centric criteria. This distinction must be made by both the treating physicians and the cancer patients themselves. Many oncologists in their daily clinical practice follow their patients' malignant disease by means of repeated imaging studies and make decisions about continuing therapy on the basis of both objective and symptomatic criteria. It is not intended that these RECIST guidelines play a role in that decision making, except if determined appropriate by the treating oncologist.
Features
The RECIST specification establishes a minimum size for measurable lesions, limits the number of lesions to follow and standardizes unidimensional measures.
Eligibility
Only patients with measurable disease at baseline should be included in protocols where objective tumor response is the primary endpoint.
Measurable disease – the presence of at least one measurable lesion.
The public source identifies “Response evaluation criteria in solid tumors” as internationally recognized set of published rules used for evaluation of cancer treatment. This brief keeps that definition visible, then builds a research path around Response, evaluation and criteria.
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