Quisinostat
chemical compound
Quisinostat (USAN; development code JNJ-26481585) is an experimental drug candidate for the treatment of cancer. It is a "second generation" histone deacetylase inhibitor with antineoplastic activity. It is highly potent against class I and II HDACs.
History
It was developed by Janssen Pharmaceuticals and licensed to NewVac LLC.
Preclinical studies show that quisinostat amplifies HDAC-repressed expression of E-cadherin, leading to a reversal of epithelial to mesenchymal transition in tumor cells.
Clinical trials
Results of a phase I trials in patients with multiple myeloma in combination with bortezomib and dexamethasone were published in 2016.
This brief starts where responsible research should: with the source description of “Quisinostat” as chemical compound. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as chemical compound. Its deeper value depends on whether names, dates, institutions and citations support that framing.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Dec 27, 2025. The linked authority identifier is Q7272620. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2016.
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This entry incorporates text from “Quisinostat” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.