Quinpirole
chemical compound
Quinpirole (developmental code name LY-171555) is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. It is used in scientific research. Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats. Another study in rats show that quinpirole produces significant THC-like effects when metabolic degradation of anandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by cannabinoid CB1 receptors. Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction.
Experiments in flies found quinpirole may have neuroprotective effects against Parkinson's disease-like pathology. Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.
Another study involving mice that had their N-ethylmaleimide-sensitive factor deleted found that the mice exhibited ADHD behaviors and that administering quinpirole alleviated the behaviors. This opens the door to a potential new avenue of ADHD treatment.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 17, 2026. The linked authority identifier is Q253187. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Quinpirole” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.