Methoxamine
chemical compound
Methoxamine, sold under the brand names Vasoxine, Vasoxyl, and Vasylox among others, is a sympathomimetic medication used as an antihypotensive agent. It has mostly or entirely been discontinued. The drug is an α1-adrenergic receptor agonist.
Medical uses
The long duration of action of methoxamine has been said to have rendered it obsolete in modern clinical practice.
Pharmacology
Methoxamine is an α1-adrenergic receptor agonist. It is described as a long-acting α1-adrenergic receptor agonist and this is contrasted with phenylephrine which is said to be short-acting. Phenylephrine is 5 to 10 times more potent than methoxamine and has a 3-fold higher maximal effect.
Chemistry
Methoxamine, also known as 2,5-dimethoxy-β-hydroxy-α-methylphenethylamine or as 2,5-dimethoxy-β-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative.
Analogues
Analogues of methoxamine include desglymidodrine (2,5-dimethoxy-β-hydroxyphenethylamine), dimetofrine (3,5-dimethoxy-4,β-dihydroxy-N-methylphenethylamine), 2,5-dimethoxyamphetamine (2,5-DMA), butaxamine ((1S,2S)-2,5-dimethoxy-β-hydroxy-N-tert-butylamphetamine), methoxyphenamine (2-methoxy-N-methylamphetamine), and β-hydroxyamphetamine (e.g., phenylpropanolamine, norpseudoephedrine), among others.
History
Methoxamine was synthesized by 1944.
“Methoxamine” enters the record as chemical compound. Crown Archives preserves that source wording while asking what Methoxamine, chemical and compound can confirm, complicate or overturn.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jul 23, 2026. The linked authority identifier is Q685119. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1944.
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This entry incorporates text from “Methoxamine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.