Pomeranz–Fritsch reaction
reaction in organic chemistry
The Pomeranz–Fritsch reaction, also named Pomeranz–Fritsch cyclization, is a named reaction in organic chemistry. It is named after Paul Fritsch (1859–1913) and Cäsar Pomeranz (1860–1926). In general it is a synthesis of isoquinoline.
General reaction scheme
The reaction below shows the acid-promoted synthesis of isoquinoline from benzaldehyde and a 2,2-dialkoxyethylamine.
Various alkyl groups, e.g. methyl and ethyl groups, can be used as substituent R.
In the archetypical reaction sulfuric acid was used as proton donor, but Lewis acids such as trifluoroacetic anhydride and lanthanide triflates have been used occasionally.
Later, a wide range of diverse isoquinolines were successfully prepared.
Reaction mechanism
A possible mechanism is depicted below:
First the benzalaminoacetal 1 is built by the condensation of benzaldehyde and a 2,2-dialkoxyethylamine. After the condensation a hydrogen-atom is added to one of the alkoxy groups. Subsequently, an alcohol is removed.
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