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Antioxidant effect of polyphenols and natural phenols

hypothetical type of antioxidant

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 5, 2026
Entity authorityQ867060
Source-derived summary

A polyphenol antioxidant is a hypothesized type of antioxidant studied in vitro. Numbering over 4,000 distinct chemical structures mostly from plants, such polyphenols have not been demonstrated to be antioxidants in vivo.

In vitro at high experimental doses, polyphenols may affect cell-to-cell signaling, receptor sensitivity, inflammatory enzyme activity or gene regulation. None of these hypothetical effects has been confirmed in humans by high-quality clinical research, as of 2025.

Food sources

Polyphenols are found in brightly colored foods, such as blackberries, blueberries, black currants, cherries, cranberries, grapes, plums, raspberries, aronia berries, and elderberries. Some vegetables, such as kale, raw red cabbage, and raw red onions, contain polyphenols, as do red wines, chocolate, black tea, green tea, pecans, and cinnamon.

Biochemical theory

The regulation theory considers a polyphenolic ability to scavenge free radicals and up-regulate certain metal chelation reactions. Various reactive oxygen species, such as singlet oxygen, peroxynitrite and hydrogen peroxide, must be continually removed from cells to maintain healthy metabolic function. Diminishing the concentrations of reactive oxygen species can have several benefits possibly associated with ion transport systems and so may affect redox signaling. There is no substantial evidence, however, that dietary polyphenols have an antioxidant effect in vivo.

Editorial summary

This brief starts where responsible research should: with the source description of “Antioxidant effect of polyphenols and natural phenols” as hypothetical type of antioxidant. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA concise reference frame for defining the subject, testing terminology and identifying the institution closest to the evidence. The current lead gives the account dated anchors—2025—that can be checked directly. The selected authority fields contribute no independent date. The account is most persuasive where Antioxidant, effect and polyphenols can be independently traced.
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Why this record matters

The subject matters to the general reference register because the source frames it as hypothetical type of antioxidant. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Jul 5, 2026. The linked authority identifier is Q867060. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2025.

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This entry incorporates text from Antioxidant effect of polyphenols and natural phenols” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.