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Plakophilin-1

protein-coding gene in the species Homo sapiens

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Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionSep 22, 2026
Entity authorityQ18030570 ↗
Source-derived summary

Plakophilin-1 is a protein that in humans is encoded by the PKP1 gene.

Function

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome.

Interactions

PKP1 has been shown to interact with Desmoplakin.

Editorial summary

“Plakophilin-1” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what Plakophilin-1, protein-coding and gene can confirm, complicate or overturn.

Editorial reviewA practical orientation to terminology and classification, particularly when read beside dated observations, specimens or technical literature. The current 85-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Plakophilin-1, protein-coding and gene.
Editorial analysis

Why this record matters

“Plakophilin-1” is worth following because a concise public description often conceals a longer documentary argument. Here, Plakophilin-1, protein-coding and gene provides the most credible route into that argument.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 22, 2026. The linked authority identifier is Q18030570. None of the 0 selected statements returned an explicit reference.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

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  • Current terminology
  • Classification context
  • Finding cited technical literature
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Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “Plakophilin-1”, its source revision and the description used here.
  2. Expand the search: follow Plakophilin-1 primary sources, Plakophilin-1 archive and Plakophilin-1 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

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  2. Which observation, specimen, dataset or publication supports the account?
  3. Has classification or technical consensus changed since the cited source?
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Source & attribution

This entry incorporates text from “Plakophilin-1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.