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Sulfadiazine

chemical compound

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionFeb 9, 2026
Entity authorityQ2555060
Source-derived summary

Sulfadiazine is an antibiotic. Used together with pyrimethamine, a dihydrofolate reductase inhibitor, it is the treatment of choice for toxoplasmosis, which is caused by a protozoan parasite. It is a second-line treatment for otitis media, prophylaxis of rheumatic fever, chancroid, chlamydia, and infections by Haemophilus influenzae. It is also used as adjunct therapy for chloroquine-resistant malaria and several forms of bacterial meningitis. It is taken by mouth. Sulfadiazine is available in multiple generic tablets of 500 mg. For urinary tract infections, the usual dose is 4 to 6 grams daily in 3 to 6 divided doses.

Common side effects include nausea, diarrhea, headache, fever, rash, depression, and pancreatitis. It should not be used in people who have severe liver problems, kidney problems, or porphyria. If used during pregnancy, it may increase the risk of kernicterus in the baby.

Editorial summary

“Sulfadiazine” enters the record as chemical compound. Crown Archives preserves that source wording while asking what Sulfadiazine, chemical and compound can confirm, complicate or overturn.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current 138-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Sulfadiazine, chemical and compound.
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“Sulfadiazine” is worth following because a concise public description often conceals a longer documentary argument. Here, Sulfadiazine, chemical and compound provides the most credible route into that argument.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Feb 9, 2026. The linked authority identifier is Q2555060. None of the 0 selected statements returned an explicit reference.

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This entry incorporates text from Sulfadiazine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.