Pepscan
Open-knowledge reference entry
Pepscan is a procedure for mapping and characterizing epitopes involving the synthesis of overlapping peptides and analysis of the peptides in enzyme-linked immunosorbent assays (ELISAs). The method is based on combinatorial chemistry and was pioneered by Mario Geysen and coworkers.
Rob Meloen was one of Geysen's co-workers. He also played an important role in the development of numerous other new technologies, including vaccine and diagnostic product development for several viral diseases. From 1994 to 2010, Meloen was Professor of Special Appointment (Chair: Biomolecular Recognition) at Utrecht University. He was one of the co-founders of the company Pepscan (Lelystad, the Netherlands) and became Scientific Director (CSO). Pepscan is now part of the Biosynth Group.
Twenty-five years later, the Pepscan methodology, evolved and modernized with the latest insights, is still an important part of Pepscan’s epitope mapping platform, which is instrumental in therapeutic antibody development.
“Pepscan” enters the record as open-knowledge reference entry. Crown Archives preserves that source wording while asking what Pepscan, Open-knowledge and entry can confirm, complicate or overturn.
Why this record matters
“Pepscan” is worth following because a concise public description often conceals a longer documentary argument. Here, Pepscan, Open-knowledge and entry provides the most credible route into that argument.
Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Mar 10, 2023. The linked authority identifier is Q7166477. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1994 and 2010.
A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Pepscan”, its source revision and the description used here.
- Expand the search: follow Pepscan primary sources, Pepscan archive and Pepscan research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Pepscan”?
- Which institution is responsible for the underlying evidence?
- What terminology or title could unlock a more precise catalogue search?
Search terms from this dossier
This entry incorporates text from “Pepscan” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.