PRKACB
protein-coding gene in the species Homo sapiens
cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the protein kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is a member of the serine/threonine protein kinase family and is a catalytic subunit of PKA. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.
Interactions
PRKACB has been shown to interact with Ryanodine receptor 2 and Low affinity nerve growth factor receptor.
“PRKACB” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what PRKACB, protein-coding and gene can confirm, complicate or overturn.
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“PRKACB” is worth following because a concise public description often conceals a longer documentary argument. Here, PRKACB, protein-coding and gene provides the most credible route into that argument.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 14, 2026. The linked authority identifier is Q18030760. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “PRKACB” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.