PQBP1
protein-coding gene in the species Homo sapiens
Polyglutamine-binding protein 1 (PQBP1) is a protein that in humans is encoded by the PQBP1 gene.
Polyglutamine binding protein-1, which was identified as a binding protein to the polyglutamine tract sequence, is an evolutionally conserved protein expressed in various tissues including developmental and adult brains or mesodermal tissues. In cells, PQBP1 is dominantly located in the nucleus but also in the cytoplasm dependently on the cell type and stress conditions. PQBP1 has recently been found to play a role in the innate immune response of dendritic cells.
It should be of note that PQBP1 has no relationship with QBP1, an artificial synthetic peptide.
Function
PQBP1 is a nuclear polyglutamine-binding protein that contains a WW domain.
The molecular roles of PQBP1 are mainly in mRNA splicing and transcription. PQBP1 interacts with splicing proteins and RNA-binding proteins. PQBP1 deficiency critically affects mRNA splicing of cell cycle and synapse related genes. Recent results indicated implication of PQBP1 in cytoplasmic RNA metabolism and elongation of protein translation from mRNA. Research also seems to suggest that PQBP1 also plays a role in the innate immune system as a necessary adaptor for the cGAS-mediated innate response to lentiviruses such as HIV1.
Begin with the source’s own compact description: “PQBP1” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through PQBP1, protein-coding and gene, not as a finished interpretation.
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The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Sep 15, 2026. The linked authority identifier is Q18035013. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “PQBP1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.