PPP2R1B
protein-coding gene in the species Homo sapiens
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the PPP2R1B gene.
Function
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Defects in this gene could be the cause of some lung and colon cancers. At least two transcript variants encoding different isoforms have been found for this gene.
Discovery
The PPP2R1B gene was discovered as part of the Human Genome Project research center focused on chromosome 11.
Clinical significance
Somatic alterations in PPP2R1B have been identified in colorectal and lung cancer tumors and cell lines, with evidence that these alterations affect protein function, supporting a role for PPP2R1B as a candidate tumor suppressor gene in these cancers. Experimental studies have shown that suppression of PPP2R1B expression enables immortalized human cells to become tumorigenic, and that the wild-type protein forms a complex with the small GTPase RalA. These findings support the role of PPP2R1B as a tumor suppressor involved in regulating RalA function.
The public source identifies “PPP2R1B” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around PPP2R1B, protein-coding and gene.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jun 26, 2026. The linked authority identifier is Q18030719. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “PPP2R1B” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.