Elafin
mammalian protein found in Homo sapiens
Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.
Function
This gene encodes an elastase-specific protease inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.
Clinical significance
Elafin has been found to have utility in serving as a biomarker for graft versus host disease of the skin.
Elafin plays some role in gut inflammation.
The public source identifies “Elafin” as mammalian protein found in Homo sapiens. This brief keeps that definition visible, then builds a research path around Elafin, mammalian and protein.
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This entry incorporates text from “Elafin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.