PEG3
protein-coding gene in the species Homo sapiens
Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene. PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction. PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.
Interactions
PEG3 has been shown to interact with SIAH2 and SIAH1.
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The public source identifies “PEG3” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around PEG3, protein-coding and gene.
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A short description can identify a subject without explaining its stakes. For “PEG3”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Oct 4, 2025. The linked authority identifier is Q18030445. None of the 0 selected statements returned an explicit reference.
A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
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Questions for further research
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This entry incorporates text from “PEG3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.