PDCD6IP
protein-coding gene in the species Homo sapiens
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene.
This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.
Function
PDCD6IP protein is part of ESCRT pathway. It participates in the membrane scission of the revers topology budding and participates in multivesicular body formation. It is also vital at the later stages and for successful completion of cytokinesis.
Interactions
PDCD6IP has been shown to interact with PDCD6.
This brief starts where responsible research should: with the source description of “PDCD6IP” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Aug 13, 2026. The linked authority identifier is Q18034955. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “PDCD6IP” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.